When GERD Causes Persistent Cough

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The incidence of ulcers of the stomach and duodenum and their response to medical therapy, in patients with Zollinger-Ellison syndrome is well described. However, reflux esophagitis is less well recognized. In this study we determined the frequency of reflux esophagitis in 122 patients with Zollinger-Ellison syndrome and examined their response to medical therapy. Esophageal symptoms, endoscopic abnormalities, or both were present in 61% of patients. Forty-five percent of patients had esophageal symptoms consisting of heartburn, dysphagia, or both.

A recent study suggests that dietary choices may be as effective as using proton pump inhibitors (PPIs) in treating acid reflux. The prevalence rate of reflux esophagitis (RE) in Asia, including Taiwan, has increased dramatically in recent years. However, few studies have discussed on its relationship with metabolic syndrome (MetS). This study aimed to evaluate the correlation between RE and MetS and its components. [6, 21,23].

Metabolic syndrome and gastro-esophageal reflux: A link towards a growing interest in developed countries

Patients with MetS have a high risk of cardiovascular disease, diabetes mellitus, and other atherosclerotic diseases [16,23,24]. A retrospective case-control study in China in 2010 found that a high waist-hip ratio, hyperglycemia, hypertriglyceridemia, and MetS were the associated factors for RE, and that HDL-C was associated with a reduced risk of RE in men [25]. This population- based cross-sectional study was conducted in a one-stage randomized clustered sample of adult inhabitants in Kerman city in 2011-2012. A total of 2265 subjects with age range of 15-85 years were enrolled.

In this article, we describe the causes and prevention of heartburn, as well as remedies that can help. Learn more about heartburn here. Acid reflux usually produces heartburn, whether it is due to a single episode of overeating or persistent GERD. Acid reflux is when some of the acid content of the stomach flows up into the esophagus, into the gullet, which moves food down from the mouth. Despite the name, heartburn has nothing to do with the heart.

The other 33% of patients required an increase in medication to lower acid output to less than 5 mEq/h in 7% and less than 1 mEq/h in the other 26% to resolve symptoms and signs completely. We conclude that reflux esophagitis occurs in the majority of patients with Zollinger-Ellison syndrome and responds well to medical therapy, although one third of patients require intensive antisecretory medication. Gastroesophageal reflux disease (GERD) is the long-term, regular occurrence of acid reflux.

It has also been recognized as an alternative treatment for acid reflux and other gastrointestinal disorders. However, more research is needed to confirm its effects on improving stomach acid. Treating low stomach acid depends on the underlying cause. If you’ve been prescribed antacid medication for your heartburn symptoms, your doctor may change your prescription to avoid triggering hypochlorhydria symptoms.

What do we see in terms of mucosal damage? An otolaryngologist would describe a variety of classic findings from laryngopharyngeal reflux.

  • A recent study suggests that dietary choices may be as effective as using proton pump inhibitors (PPIs) in treating acid reflux.
  • Efficacy (healing, symptom relief) and cost-effectiveness are the principal reasons for the rapidly increasing use of proton pump inhibitors (PPIs) for the management of gastro-oesophageal reflux disease.
  • This population- based cross-sectional study was conducted in a one-stage randomized clustered sample of adult inhabitants in Kerman city in 2011-2012.
  • The “ringed” or “corrugated” esophagus is a cause of chronic dysphagia and recurrent food impactions in young men.

Acid reflux creates a burning pain in the lower chest area, often after eating. Exact figures vary, but diseases resulting from acid reflux are the most common gut complaint seen by hospital departments in the United States.

Their laryngeal inflammation can worsen even though their GERD has resolved. In the prospective trials on GERD and laryngopharyngeal reflux disease, when they performed a meta-analysis, it suggested that these patients have increased response to antireflux therapy.

When GERD Causes Persistent Cough

Patients who are unresponsive to 4-8 weeks’ treatment with PPIs twice daily might have so-called refractory GERD. The first investigation these patients should undergo is upper endoscopy to exclude a diagnosis of peptic ulcer disease or cancer and identify the presence of esophagitis. The presence of esophagitis in these patients is suggestive of a pill-induced injury, an autoimmune skin disease involving the esophagus, eosinophilic esophagitis or, less likely, a hypersecretory syndrome or a genotype that confers altered metabolism of PPIs.

Full text of “Ten thousand words often mispronounced;”

The underlying presenting symptoms of heartburn, regurgitation, and indigestion may be the only predictors we have in patients who present with laryngopharyngeal reflux disease-associated symptoms. So, I consider these symptoms when I take a GERD history. The idea of “silent GERD” causing these symptoms as a “tip of the iceberg” phenomenon is not likely in most patients. Gastroesophageal reflux disease (GERD) is diagnosed when acid reflux occurs more than twice a week.

When this muscle fails to close, the acid-containing contents of the stomach can travel back up into the esophagus. This backward movement is called reflux. Laryngopharyngeal reflux (LPR) is a condition in which acid that is made in the stomach travels up the esophagus (swallowing tube) and gets to the throat.

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